Unlock the Cannabis Code: How THC & CBD Alter Your Brain & Body!
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Unlock the Cannabis Code: How THC & CBD Alter Your Brain & Body!

Ari Horesh

Did you know that cannabis impacts your brain and body within just 30 seconds of ingestion? Discover the fascinating dynamics between cannabis and your brain with Dr. Andrew Huberman, a neuroscientist renowned for his compelling, yet straightforward explanations of complex neurological processes.

"Cannabis is very fast to enter the bloodstream. In fact, within 30 seconds, it's going to enter the brain and permeate throughout the brain and body," states Dr. Huberman.

Cannabis contains several compounds, notably tetrahydrocannabinol (THC) and cannabidiol (CBD), which are delivered swiftly into your system. The rate at which these compounds reach their peak concentrations within your body and subsequently elicit their biological effects is faster than many other substances, like alcohol or nicotine.

One critical aspect to note is that THC, CBD, and other cannabis components are lipophilic. That means they can effectively pass through fatty tissues, and even remain in those cells for an extended period. This fact reveals why cannabis can often be detected in a person's system for as long as 80 days post-ingestion.

Cannabis influences us by binding to endocannabinoid receptors in our body, particularly in our neurons. Dr. Huberman elaborates,

"The components that are psychoactive get into the bloodstream are immediately able to access neurons and other cells and start having these effects of parking at those endogenous cannabinoid receptors and impacting the signaling between neurons."

The effects of cannabis are highly variable and subjective. It hinges on many factors, including the variety of cannabis (indica or sativa), individual metabolism, and the person's familiarity with the compound.

Dr. Huberman points out the unique attributes of different cannabis strains:

  • Sativa: Known for its invigorating effects, it often elevates mood, enhances alertness, and may even increase focus.
  • Indica: Typically offers more sedative, relaxing qualities.
"The sativas tend to meet people mood elevated, energetic, again, the head high. And indica varieties tend to do the opposite, more of a sedative, relaxant," explains Dr. Huberman.

The secret to these diverse effects lies within the brain structures that these cannabinoids target. For instance, THC and CBD stimulate CB1 receptors in the prefrontal cortex (PFC), a brain area associated with decision-making, personality, and social behavior. The activation of the PFC can lead to increased focus and reduction in stress.

Interestingly, these cannabinoids can also reduce activation in the amygdala, a brain region responsible for processing fear and anxiety. This dual action on different brain structures underscores the potential for cannabis to have opposing effects on mood and anxiety.

The story doesn't end there. THC and CBD also influence other parts of the brain, such as the hippocampus (involved in memory) and basal ganglia (related to action planning). Consequently, different strains and doses of cannabis can lead to varying cognitive, motor, and emotional effects.

It's crucial to remember, though, that individual responses to cannabis can be unpredictable. As Dr. Huberman emphasizes,

"There is no way to predict what the effect of a given plant can be"

We now explore another fascinating aspect of cannabis - its ability to increase or decrease one's focus. This is largely due to its activation of CB1 receptors in the so-called prefrontal cortex, which is right behind the forehead. As Dr. Huberman describes, the prefrontal cortex acts as a kind of "rein" on our stress-detection systems. It's like pulling back on a horse that is running away. When cannabis activates this area, it has the potential to reduce stress and increase focus.

However, not all users experience this effect. In fact, some people find that cannabis, particularly sativa strains, can trigger anxiety and paranoia. This can occur regardless of the cannabis type - whether it's a type I, II, or III variety, or a hybrid strain.

"Everything we know about the way that THC and CBD work is that they tend to potentiate, that is increase the effects of these different systems at given synapses and in different areas of the brain and body. That is if someone experiences paranoia or anxiety from cannabis, smoking more or ingesting more is not going to alleviate that. It's going to exacerbate it," warns Dr. Huberman.

The key to understanding cannabis' impact on the brain lies in its interaction with various neural systems. Whether a person consumes sativa, indica, or a hybrid strain, can lead to different results. What's important to remember is that the effects of any strain can't be predicted for an individual.

"Depending on dosage but also depending on pre-existing neural circuitry and propensity for anxiety, some people ingest or smoke sativa varieties, and regardless of whether or not it's a type I, type II, or type III variety, or a hybrid strain, they experience paranoia," the neuroscientist explains.

"And perhaps most importantly, even if you didn't understand anything that I've said about the biology of these different strains and the receptors, please do understand that there is no way to predict what the effect of a given strain will be on an individual."

This unpredictability underscores the need for caution, especially when the THC content is unknown. Despite the increasing commercialization and regulation of THC and CBD products, many people still consume cannabis through sources where the exact amount they're ingesting is unclear.

Dr. Huberman delves further into the various effects of THC and CBD on different brain regions. For instance, memory deficits associated with cannabis consumption are due to reductions in electrical activity within a brain region called the hippocampus. The calming effects of indica strains result from decreased electrical activity in the prefrontal cortex, inhibiting the ability to perform complex tasks requiring forward thinking and planning.

Even the notorious "munchies" that often accompany cannabis use have a neurological explanation. CB1 receptors in the hypothalamus bind to THC and CBD, activating neurons that strongly stimulate appetite.

"One within the brain, one within the body increasing appetite. And so there's an array of different effects," Dr. Huberman observes.

In conclusion, while cannabis may offer a range of benefits and effects due to its complex interactions with the nervous system, its use should always be approached with a comprehensive understanding of these interactions and the potential risks involved. As Dr. Huberman's enlightening discussion reveals, there is still much to learn about the influence of cannabis on our brains and bodies.

This article aims to provide a general understanding and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a healthcare provider for any health-related concerns.

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